we have validated that patients with intermediate baseline serum tryptase levels (8-11 ng/mL) and without skin involvement have a higher risk of severe venom induced anaphylaxis.
Wojciech Francuzik, Franziska Ruëff, Andrea Bauer, Maria Beatrice Bilò, Victoria Cardona, George Christoff, Sabine Dölle-Bierke, Luis Ensina, Montserrat Fernández Rivas, Thomas Hawranek, Jonathan O’B Hourihane, Thilo Jakob, Nicos G Papadopoulos, Claudia Pföhler, Iwona Poziomkowska-Gęsicka, Xavier Van der Brempt, Kathrin Scherer Hofmeier, Regina Treudler, Nicola Wagner, Bettina Wedi, Margitta Worm
JACI,
2021
We aimed to analyze the treatment courses of pemphigus patients and the clinical responses regarding therapy changes.
R. Scarpone, W. Francuzik, M. Worm, G. Heine
Front Med (Lausanne),
2020
We investigated adult patients with grass pollen–induced allergic rhinoconjunctivitis ± allergic asthma and low serum 25(OH)D.
G. Heine, W. Francuzik, S. Doelle‐Bierke, G. Drozdenko, S. Frischbutter, N. Schumacher, A. Radbruch, M. Worm
Allergy,
2020
Atopic dermatitis (AD) is a frequent chronic remittent skin disease. The pathophysio-logy of AD has been increasingly better understood within the last years. This may help to identify different endotypes which are suitable for defined therapies. A patient oriented therapy considers besides phenotypical features also genetic and biologi-cal markers. The most recent developments regarding biologics and small molecule drugs are presented in this article. Such molecules will change the treatment perspec-tives for atopic dermatitis in the future if they will be approved. Dupilumab is the first approved biologic for the treatment of moderate to severe atopic dermatitis in adolescence and adulthood and has led to a significant impro-vement of the treatment of this chronic disease. In the present article we show real-li-fe data on the efficacy of dupilumab in adult dermatitis patients and discuss other relevant data, but also open questions, which are important for the standard care of atopic dermatitis patients.
Margitta Worm, Wojciech Francuzik, Magdalena Kraft, Aikaterina Alexiou
JDDG,
2020
To uncover the mechanisms by which skin barrier disruption elicits TSLP production and to delineate the level at which individual mechanistic components may converge.
D. Redhu, K. Franke, V. Kumari, W. Francuzik, M. Babina, M. Worm
Br J Dermatol,
2020
In the present analysis, we aimed to evaluate the management and risk factors of refractory anaphylaxis to highlight possible clinical implications for updating current management algorithms.
W. Francuzik, S. Dölle, M. Worm
Exp Rev Clin Immun,
2018
Preventive measures to decrease the frequency and intensity of anaphylactic events are essential to provide optimal care for allergic patients. Aggravating factors may trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided. Our data suggest it may be possible to identify patients who require intensified preventive measures due to their relatively higher risk for severe anaphylaxis by considering endogenous and exogenous factors.
Margitta Worm, Wojciech Francuzik, Jean-Marie Renaudin, Maria Beatrice Bilo, Victoria Cardona, Kathrin Scherer Hofmeier, Alice Köhli, Andrea Bauer, George Christoff, Ewa Cichocka-Jarosz, Thomas Hawranek, Jonathan OB Hourihane, Lars Lange, Vera Mahler, Antonella Muraro, Nikolaos G Papadopoulos, Claudia Pföhler, Iwona Poziomkowska-Gęsicka, Franziska Ruëff, Thomas Spindler, Regina Treudler, Montserrat Fernandez-Rivas, Sabine Dölle
Allergy,
2018
We read with great interest the article “Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production” by Hox et al.1 Therein, the authors provide experimental evidence that female mice exhibit more severe anaphylactic reactions than do their male counterparts and offer mechanistic insights by showing that estrogen promotes vascular leakage during an anaphylactic event via enhanced nitric oxide production.
W. Francuzik, M. Nassiri, M. Babina, M. Worm
JACI,
2015